Research Journal of Pharmacy and Technology

Ainun Sajidah ¹, Evi Risa Mariana ¹, Zainab ¹

Affiliations
1 Poltekkes Kemenkes Banjarmasin,, ID

Abstract

The blood glucose level of the body tends to increase slightly after the age of 50. The coriander (Coriandrum sativum L) is a member of the Apiaceae family and it grows in a wide range conditions and can be used as antidiabetic. The purpose of this study was to determine the effect of coriander water extract on the blood sugar levels of white rats (Rattus norvegicus strain wistar). The method of this study involved experimental animals, specifically 20 Rattus norvegicus strain wistar ranging from 150-200grams with an age between 2-3 months. The mice were injected with an alloxan solution to induce a diabetic condition and then they were divided into four groups and treated. The treatments were 0.5% Na CMC, glibenclamide 0.45mg/Kg b.w, coriander extract of 100mg/Kg b.w and coriander extract of 200mg/Kg b.w for 15 days. The blood glucose level of the mice was measured on days 0, 1, 5, 10 and 15. The results showed that the 0.5% CMC placebo had no effect in terms of reducing the glucose level of the rats, Glibenclamide 0.45mg/Kg b.w had an effect in terms of reducing the blood glucose level, as did coriander extract 100mg/Kg b.w and 200mg/Kg b.w among the alloxan-diabetic mice.

Keywords

Diabetic, Blood glucose, Coriander seed, Mice, Alloxan.

Full Text

     

Zainab ¹

Affiliations
1 Poltekkes Kemenkes Banjarmasin, ID

Abstract

One of factors that influences the immunization coverage below the global target is immunization adverse events as well as local reactions, such as pain. The aim of this study was to measure the effect of topical shallots and whether they reduce the incidence of immunization adverse events in infants aged 0 - 11 months, especially the level of pain. This study used a quasi-experimental design with a pre-post design. The sample was infants aged 0 - 11 months. The experimental group consisted of 15 participants and the control group consisted of 15 participants. The pain was measured using the NIPS (Neonatal Infant Pain Scale). In this study, the experimental group was given shallots (Allium Cepa L. Var aggregatum) topically before they were rubbed around the area of the injection. The control group was not given any intervention. We measured the pain every day until 3 days post-immunization. The data was analyzed using the Wilcoxon Sign Rank test. The study showed that there were changes in the level of pain in the experimental group on day 1, day 2, and day 3 post-immunization (p < 0.05). There were also changes in the level of pain in the control group on day 1, day 2 and day 3 (p < 0.05). The frequency distribution data showed that no respondents experienced pain in the experimental group, whereas in the control group, there were still two respondents who experienced mild pain. This study recommends using shallots topically, where they are rubbed around the injection area to reduce the local reaction and pain.

Keywords

Shallots, pain, infant, immunization, Allium sepa L. Var aggregatum.

Full Text